利福平是治疗麻风病很有效的药物,但对肝脏的毒性和价昂是其缺点。许多人提出过剂量的问题。Kenwright等曾在健康志愿者证明加用丙磺舒(Probenecid)-化学结构为P-(di-n-propyl sulfamyl)-benzoic acid,它是一种苯甲酸的衍化物,又名羧苯磺丙胺,可提高血清中利福平的浓度。以后Katoch等(1980)报告在非瘤型病人,它可显著地提高利福平的血清浓度。本 Rifampicin is a very effective drug for the treatment of leprosy, but its toxicity and high price are its disadvantages. Many people have raised the issue of dosage. Kenwright et al. Demonstrated in healthy volunteers that Probenecid - the chemical structure of P- (di-n-propyl sulfamyl) -benzoic acid, is a derivative of benzoic acid, also known as cefotaxime , Can increase the concentration of rifampin in serum. Later Katoch et al. (1980) reported that in non-neoplastic patients, it significantly increased the serum concentration of rifampicin. this