弱精症是一种常见的男性不育疾病,表现为精子前向运动能力的减退,其病因尚不明确。DJ-1蛋白广泛存在于肝脏、骨骼肌、肾脏、大脑和睾丸,与包括男性不育症在内的许多疾病相关。本文旨在说明DJ-1对精子的内源性抗氧化作用与弱精症有关,DJ-1的抗氧化作用可能成为弱精症治疗的潜在靶点。 Asthenozoospermia is a common male infertility disease, manifested as the decline of sperm motility, the etiology is not yet clear. DJ-1 protein is widespread in the liver, skeletal muscle, kidney, brain and testis and is associated with many diseases, including male infertility. This article aims to demonstrate that endogenous anti-oxidant effects of DJ-1 on sperm are associated with asthenospermia and that the anti-oxidant effect of DJ-1 may be a potential target for the treatment of asthenospermia.