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对262例无症状HBsAg携带者(ASC)进行为期4年血清流行病学随访。应用Logistic回归模型拟合结果表明,HBsAg持续携带的危险因素为ASC的HBsAg滴度和居住地区。在α=0.05水平上建立的二因素模型下,HBsAg滴度的OR和标准化β_k均为最大。因此,ASC的HBsAg滴度是HBsAg持续携带的主要影响因素。在HBsAg持续携带者中HBsAg高滴度组(≥1:256)的adr亚型检出率(78.33％)高于低滴度组(≤1:128)的adr亚型测出率(57.14％),可能是由于adr亚型毒株具有HBsAg持续性趋向所致。
A total of 262 asymptomatic HBsAg carriers (ASC) were followed up for 4 years. The results of fitting with Logistic regression model showed that the risk factors of persistent HBsAg were HBsAg titers and living areas of ASC. Under the two-factor model established at the level of α = 0.05, the OR of HBsAg titers and the normalized β_k were the highest. Therefore, the HBsAg titers of ASC are the main influencing factors of HBsAg persistence. The detection rate of adr subtype (78.33%) in HBsAg high titer group (≥1: 256) was higher than that in low titer group (≤1: 128) in HBsAg continuous carriers (57.14% ), Probably due to the persistence of HBsAg in subtype adr strains.