氨是蛋白质代谢的一种中间产物,对机体具有毒性。在正常生理情况下,氨虽在体内不断生成,但其大部分在肝中合成尿素而消失,另一小部分则可与谷氨酸结成谷氨酰胺。这是机体解除氨毒的二种主要方式。前一方式只在肝中进行,后一方式也可以在肝中进行;所以肝脏是氨代谢与解毒的主要器官。 Ammonia is an intermediate product of protein metabolism and is toxic to the body. Under normal physiological conditions, ammonia is continuously produced in the body, but most of it disappears from the synthesis of urea in the liver, and a small part of it can form glutamine with glutamate. This is the two main ways the body releases ammonia poisoning. The former method is only performed in the liver, and the latter method can also be performed in the liver; therefore, the liver is the main organ for ammonia metabolism and detoxification.