胰岛素是治疗胰岛素依赖性糖尿病的主要药物,长期以来一直是注射给药,这给患者造成很大不便,因此国内外医药界一直在致力于胰岛素非注射途径给药的研究。但是,胰岛素是大分子蛋白质,经非注射途径给药时,难以通过粘膜或皮肤屏障,必须采取适当的措施以促进胰岛素的吸收,其中,较为有效也是应用较多的是采用吸收促进剂。因此,研究开发无毒高效的吸收促进剂是胰岛素非注射给药研究的重要环节。胰岛素非注射途径有口 Insulin is the main drug for the treatment of insulin-dependent diabetes mellitus, which has long been administered by injection. This has caused great inconvenience to the patients. Therefore, the pharmaceutical industry at home and abroad has been devoted to the study of administration of insulin non-injection. However, insulin is a macromolecular protein, it is difficult to pass the mucosa or skin barrier when it is administered by non-injection route. Appropriate measures must be taken to promote the absorption of insulin. Among them, more effective and more used absorption enhancer. Therefore, research and development of non-toxic and efficient absorption enhancer is an important part of non-injectable insulin study. Insulin non-injection route has mouth