目的 :探讨高渗盐水处理 ,对失血性休克兔红细胞免疫黏附功能和对大肠杆菌攻击抵抗力的影响。方法 :将 6 0只兔分为6组 ,每组 10只 ,第 1组为假休克组 :仅在局麻下插管加肝素 ;第 2、3组经颈动脉放血导致兔休克。 30min后 ,第 1、2组兔分别给予生理盐水及含 1× 10 9/kg大肠杆菌的平衡盐液 ;第 2组兔给予 75g/L盐水及含 1× 10 9/kg大肠杆菌的平衡盐液 ,然后观察 3组动物的存活率。另取兔 30只 ,分组和失血性休克模型的制作同上 ,但处理所用的平衡盐液中不含大肠杆菌。以C3b受体花环及IC花环形成实验 ,检测休克后 5h兔红细胞的免疫黏附功能。结果 :高渗盐水处理组兔红细胞C3b受体花环的形成率显著高于生理盐水治疗组 (P <0 .0 1) ;而IC花环形成率则显著低于生理盐水处理组 (P <0 .0 1)。另外 ,高渗盐水处理能显著提高失血性休克兔对大肠杆菌攻击的抵抗力。结论 :高渗盐水处理能显著增强失血性休克兔的红细胞免疫黏附功能和对大肠杆菌攻击的抵抗力 Objective: To investigate the effects of hypertonic saline treatment on erythrocyte immune adherence and esophageal resistance in hemorrhagic shock rabbits. Methods: Sixty rabbits were divided into 6 groups, 10 in each group. The first group was sham-shock group: intubation with heparin only under local anesthesia; the second and third groups were shocked by bloodletting of the carotid artery. After 30 minutes, the rabbits in group 1 and group 2 were given normal saline and balanced salt solution containing 1 × 10 9 / kg E. coli respectively. The rabbits in group 2 received 75 g / L saline and balance salt containing 1 × 10 9 / kg E.coli After that, the survival rate of the three groups of animals was observed. Another 30 rabbits were taken, grouping and hemorrhagic shock models were made as above, but the balance salt solution used in the treatment did not contain E. coli. The formation of C3b receptor rosette and IC rosette was used to detect the immune adherence function of rabbit erythrocytes 5h after shock. Results: The formation rate of C3b receptor rosette of erythrocyte erythrocytes in hypertonic saline group was significantly higher than that in saline group (P <0.01), while the rate of IC rosette formation was significantly lower than that in saline group (P <0. 0 1). In addition, hypertonic saline treatment can significantly increase the resistance of hemorrhagic shock rabbits to E. coli challenge. CONCLUSION: Hypertonic saline treatment can significantly enhance erythrocyte immune adhesion and resistance to E. coli in hemorrhagic shock rabbits