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F 蛋白是一种功能不明,分子量为44KDa 细胞浆蛋白质,主要存在肝脏,其它组织中含量甚微。由于该蛋白在肝细胞(浓度10~(-5)mol/L)和血清(浓度2.5×10~(-10)mol/L)之间浓度梯度大,及有限的组织分布,故可敏感而特异的反映肝细胞损害程度。本文作者按Oliveira 介绍的RIA 方法测定了健康人与不同类型肝病患者血清中F 蛋白含量。同时对受检者做传统的肝功能试验和肝组织学检查。结果:30例健康人血清F 蛋白含量上限为60ng/ml、46例肝病患者血清F 蛋白含量增加者占91%,而其它肝功能试验如γGT,AST 和ALP 活力升高者分别占88%,61%和52%。在该组病例中除一例伴充血性心衰患者外,均未发现肝功能试验异常而F 蛋白含量却正常的患者。经对41例过度饮酒者检查,其中90%血清F 蛋白含量增加,而AST 和γGT 活力升高者则分别为68%和83%,在这组病例
F protein is an unknown function, a molecular weight of 44KDa cytoplasmic protein, mainly in the liver, other tissues content is minimal. Because of its large concentration gradient and limited tissue distribution between hepatocytes (concentration of 10 -5 mol / L) and serum (concentration of 2.5 × 10 -10 mol / L), the protein is sensitive Specific to reflect the degree of liver damage. According to the RIA method introduced by Oliveira, the authors measured the serum F protein content in healthy people and different types of liver disease patients. At the same time on the subjects to do the traditional liver function tests and liver histology. Results: The upper limit of F protein content was 30 ng / ml in 30 healthy people, 91% in 46 liver disease patients, and 88% in other liver function tests such as γGT, AST and ALP, respectively. 61% and 52%. In this group of patients, except for one patient with congestive heart failure, no abnormal liver function test was found and F protein content was normal. After 41 alcohol overdose examination, 90% of the serum F protein content increased, and AST and γGT increased vitality was 68% and 83%, respectively, in this group of patients