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作者观察1980年以来720例新发现痰涂片阳性肺结核病例。按随机分为下列3组:第1组——利福平,异烟肼、链霉素每日1次,吡嗪酰胺每周2次,共3个月;然后利福平每日1次,异烟肼每周2次,共3个月(3 RHSZ_2/3 RH2)。第2组——利福平、异烟肼,链霉素每日1次,吡嗪酰胺每周2次,共3个月;然后异烟肼、链霉素每日1次,吡嗪酰胺每周2次,共3个月(3 RHSZ_2/3 HSZ_2)。第3组——利福平、异烟肼每日1次,乙胺丁醇每周2次,共3个月,然后异烟肼每日1次,链霉素每周2次,共6个月(3 RHE_2/6 HS_2)。将6个月间歇化疗与9个月标准化疗方案作比较。共分析704例,包括第1组259例,第2组250例,第3组195例。尚有12例失访,4例死亡。13例(1.8%)因发现治疗前所作的痰结核菌耐药性试验呈耐药性,
The authors observed 720 new cases of sputum smear-positive tuberculosis since 1980. Randomly divided into the following three groups: Group 1 - rifampicin, isoniazid, streptomycin 1 day, pyrazinamide twice a week for 3 months; then rifampicin 1 day Isoniazid twice weekly for 3 months (3 RHSZ 2/3 RH2). Group 2 - rifampicin, isoniazid, streptomycin 1 day, pyrazinamide twice a week for 3 months; then isoniazid, streptomycin 1 day, pyrazinamide 2 times a week for 3 months (3 RHSZ_2 / 3 HSZ_2). Group 3 - rifampicin, isoniazid 1 times daily, ethambutol 2 times per week for 3 months, then isoniazid 1 times daily, streptomycin 2 times per week for a total of 6 Month (3 RHE_2 / 6 HS_2). Six months of intermittent chemotherapy compared with 9 months of standard chemotherapy. A total of 704 cases were analyzed, including 259 cases in group 1, 250 cases in group 2 and 195 cases in group 3. There are still 12 cases of missing and 4 deaths. Thirteen patients (1.8%) were found to be resistant to sputum TB drug resistance test before treatment,