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目的探讨头低位卧床(head-down bed rest,HDBR)对人脑灰质密度的影响。方法 14名男性健康志愿者,进行为期30 d的-6°头低位模拟微重力卧床实验。使用3.0T超导MR成像系统采集卧床前后的高分辨率全脑解剖成像数据,用SPM8软件进行基于体素的形态学分析(VBM),比较志愿者卧床前后的脑灰质密度变化。结果卧床后志愿者双侧丘脑、双侧枕叶、右侧顶下小叶的灰质密度减少(P<0.005)。结论模拟微重力环境可致正常成年人脑灰质密度发生改变。
Objective To investigate the effect of head-down bed rest (HDBR) on gray matter density in human brain. Methods Fourteen male healthy volunteers were enrolled in this study. High-resolution whole-brain anatomical imaging data before and after bed rest were collected using 3.0T superconducting MR imaging system. Voxel-based morphometric analysis (VBM) was performed with SPM8 software to compare changes of gray matter density in volunteers before and after bed rest. Results After ambulation, the gray matter density of bilateral thalamus, bilateral occipital lobe and right parietal lobule decreased (P <0.005). Conclusion Simulated micro-gravity environment can cause changes of gray matter density in normal adults.