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目的:探讨食管癌组织中STAT3和p38的表达,及其在食管癌发生发展和预后中的临床意义。方法:采用免疫组化SP法检测STAT3和p38在89例食管癌组织及20例癌旁组织中的表达,并分析其与食管癌临床病理特征的联系。结果:STAT3和p38在食管癌组织中阳性率明显高于癌旁组织,P<0.05。STAT3和p38表达水平与患者的年龄、性别、组织类型及位置无关(P>0.05),而和组织分化程度呈负相关(r值分别为-0.395和-0.389,P值均<0.05),与淋巴结转移呈正相关,r值分别为0.242和0.249,P值均<0.05。两者在癌组织中的表达存在正相关关系,r=0.329,P=0.002。结论:STAT3和p38在食管癌的发生发展中起重要作用,并有助于判断恶性程度及预后。
Objective: To investigate the expression of STAT3 and p38 in esophageal carcinoma and its clinical significance in the development and prognosis of esophageal carcinoma. Methods: The expressions of STAT3 and p38 in 89 cases of esophageal cancer tissue and 20 cases of paracancerous tissues were detected by immunohistochemical SP method. The relationship between them and the clinicopathological features of esophageal carcinoma was analyzed. Results: The positive rates of STAT3 and p38 in esophageal cancer tissues were significantly higher than those in paracancerous tissues (P <0.05). The expression levels of STAT3 and p38 were not related to the age, gender, type and location of patients (P> 0.05), but negatively correlated with the degree of differentiation (r = -0.395 and -0.389, P <0.05) Lymph node metastasis was positively correlated with r values of 0.242 and 0.249 respectively, P <0.05. There was a positive correlation between their expression in cancer tissues, r = 0.329, P = 0.002. Conclusion: STAT3 and p38 play an important role in the carcinogenesis and progression of esophageal cancer, and help to determine the degree of malignancy and prognosis.