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脑恶性肿瘤虽经手术切除、放疗及静脉内化疗,其平均生存期仍然不超过16个月,经静脉全身化疗,由于受到剂量限制,全身性毒副反应较大,影响其疗效。而颈内动脉灌注化疗,可将药物有效浓度灌注到颅内肿瘤组织,减轻全身毒性反应,延长化疗药在肿瘤内的滞留时间,有效发挥化疗药对肿瘤细胞的杀伤作用。不足的是导管插在眼动脉开口以下时,化疗后常出现严重的眼及眶部并发症。近年来,随着神经介入的迅速发展,采用超选择性动脉内化疗可弥补上述不足,有效地发挥化疗药的作用。
Despite the surgical resection of brain malignant tumor, radiotherapy and intravenous chemotherapy, the average survival time is still not more than 16 months after intravenous systemic chemotherapy, due to dose restrictions, systemic toxicity, affecting its efficacy. The intra-arterial infusion chemotherapy, the effective concentration of drug infusion into the intracranial tumor tissue, reduce systemic toxicity, prolong the residence time of chemotherapy drugs in the tumor, the effective use of chemotherapy drugs on tumor cell killing effect. The disadvantage is that when the catheter is inserted below the opening of the ophthalmic artery, serious eye and orbital complications often occur after chemotherapy. In recent years, with the rapid development of nerve intervention, the use of superselective arterial chemotherapy can make up for these shortcomings and effectively play the role of chemotherapy drugs.