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Background Few studies have explored the inward sodium current (INa) kinetics of transitional cardiomyocytes.This study aimed to explore the kinetics of transitional cardiomyocytes types α and β.Methods The whole-cell patch clamp technique was used to study the rapid INa of isolated transitional cardiomyocytes in the Koch triangle of rabbit hearts.Results Maximal amplitude and density of INa in type a and type β was (-1627±988) pA (α),(-35.17±6.56) pA/pF (β) and (-3845±467) pA (α),(-65.64±10.23) pA/pF (β) (P0.05),but time constants of inactivation were significantly different at (1.10±0.19) mV (α) and (2.37±0.33) ms (β),(P