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目的探讨支气管哮喘患者血维生素D水平与肺功能的相关性。方法选择支气管哮喘患者组60例(轻中度组15例,重度组45例),健康对照组20例,用电化学发光法检测血25羟维生素D(25OHD)浓度。用肺功能仪检测哮喘患者肺功能指标:用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、FEV1占预计值%及FEV1/FVC%。结果支气管哮喘患者血维生素D水平明显低于对照组,差异有统计学意义(P﹤0.05)。重度患者组血维生素D水平明显低于轻中度组,差异有统计学意义(P﹤0.05)。结论支气管哮喘患者血维生素D水平显著降低,且降低程度与肺功能恶化程度呈正相关(r=0.825,P﹤0.05)。对哮喘患者血维生素D水平进行监测有助于评估哮喘的严重程度。
Objective To investigate the correlation between serum vitamin D levels and pulmonary function in patients with bronchial asthma. Methods Sixty patients with bronchial asthma (15 in mild to moderate group and 45 in severe group) and 20 healthy controls were enrolled in this study. The concentration of 25OHD was determined by electrochemiluminescence. Pulmonary function tests were used to detect lung function parameters of asthma patients: forced vital capacity (FVC), forced expiratory volume one second (FEV1), predicted% FEV1 and FEV1 / FVC%. Results The level of blood vitamin D in patients with bronchial asthma was significantly lower than that in the control group (P <0.05). Serum vitamin D levels in severe patients were significantly lower than those in mild to moderate groups (P <0.05). Conclusion The level of serum vitamin D in bronchial asthma patients was significantly lower than that in patients with bronchial asthma. The degree of decrease was positively correlated with the degree of pulmonary function deterioration (r = 0.825, P <0.05). Monitoring blood levels of vitamin D in asthma helps to assess the severity of asthma.