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目的:调查研究健康中老年人肺功能下降与呼吸中枢驱动变化的关系。方法:采用随机数字表法选择50例健康的中老年人与30例健康的青年人,使用多导食道电极记录隔肌肌电反映出呼吸中枢驱动,观察静息状态下最大用力吸气时的隔肌肌电。结果:观察组最大用力呼吸时隔肌肌电为(172.2±54.6)μV,与对照组的(175.0±55.7)μV相比无显著性差异(P>0.05)。观察组的呼吸中枢驱动有效性为(62.7±23.2)%,与对照组的(128.6±96.2)%相比具有显著性差异(P<0.05)。结论:中老年人的呼吸中枢驱动储备显著低于青年人,肺功能随着年龄的增加而减退的原因不是呼吸中枢驱动的下降,而是肺部结构本身的变化。
Objective: To investigate the relationship between pulmonary function decline and respiratory center drive in healthy middle-aged and elderly people. Methods: Fifty healthy middle-aged and elderly healthy people and 30 healthy young people were selected by random number table. The multi-channel esophageal electrodes were used to record the myoelectricity of the diaphragm to reflect the respiratory center drive. The maximal forced inhalation Diaphragmatic myoelectricity. Results: The maximal forced respiration creatinine in the observation group was (172.2 ± 54.6) μV, which was not significantly different from that in the control group (175.0 ± 55.7) μV (P> 0.05). The effectiveness of the respiratory center drive in the observation group was (62.7 ± 23.2)%, which was significantly different from that in the control group (128.6 ± 96.2)% (P <0.05). CONCLUSIONS: Respiratory center drive reserve for middle-aged and elderly people is significantly lower than that of young people. The reason for the decline of lung function with age is not the decrease of respiratory center drive but the change of lung structure itself.