The upper Yangtze River region is one of the most frequent debris flow areas in China. The study area contains a cascade of six large hydropower stations located along the river with total capacity of more than 70 million kilowatts. The purpose of the study was to determine potential and dynamic differences in debris flow susceptibility and intensity with regard to seasonal monsoon events. We analyzed this region’s debris flow history by examining the effective peak acceleration of antecedent earthquakes,the impacts of antecedent droughts, the combined effects of earthquakes and droughts, with regard to topography, precipitation, and loose solid material conditions. Based on these factors, we developed a debris flow susceptibility map. Results indicate that the entire debris flow susceptibility area is 167,500 km~2, of which 26,800 km~2 falls within the high susceptibility area, with 60,900 km~2 in medium and 79,800 km~2 are in low susceptibility areas. Three of the six large hydropower stations are located within the areas with high risk of debris flows. The synthetic zonation map of debris flow susceptibility for the study area corresponds with both the investigation data and actual distribution of debris flows. The results of debris flow susceptibility provide base-line data for mitigating, assessing, controlling and monitoring of debris flows hazards. The study of the upper Yangtze River region is one of the most frequent debris flow areas in China. The study area contains one of the most frequent debris flow areas in China. The purpose of the study was determined potential and dynamic differences in debris flow susceptibility and intensity with regard to seasonal monsoon events. We analyzed this region’s debris flow history by examining the effective peak acceleration of antecedent earthquakes, the impacts of antecedent droughts, the combined effects of earthquakes and droughts, with regard Based on these factors, we developed a debris flow susceptibility map. Results that the entire debris flow susceptibility area is 167,500 km ~ 2, of which 26,800 km ~ 2 falls within the high susceptibility area, with 60,900 km ~ 2 in medium and 79,800 km ~ 2 are in low susceptibility areas. Three of the six large hydropowe The synthetic zonation map of debris flow susceptibility for the study area corresponds with both the investigation data and actual distribution of debris flows. The results of debris flow susceptibility provide base-line data for mitigating, assessing, controlling and monitoring of debris flows hazards.