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目的 观察α1受体阻滞剂乌拉地尔对左心瓣膜返流所致的心力衰竭患者的血流动力学效应和临床疗效。方法 15例二尖瓣和 (或 )主动脉瓣关闭不全患者 ,平均年龄 ( 4 1 0± 16 0 )岁 ,心功能IV级 ,静注乌拉地尔 4～ 10μg/(kg·min) ,2 4h维持 3～ 5d。结果 乌拉地尔可降低总外周阻力、肺血管阻力、肺毛细血管嵌压及肺动脉压 ,增加心输出量及心脏指数。心功能明显改善 13例 ,改善者 2例 ,总有效率 10 0 %。结论 静注乌拉地尔对左心瓣膜返流所致的充血性心力衰竭有良好的血流动力学效应及临床疗效。
Objective To observe the hemodynamic effects and clinical effects of α1receptor blocker urapidil in patients with heart failure caused by left heart valve regurgitation. Methods Fifteen patients with mitral valve and / or aortic valve regurgitation were enrolled in this study. The mean age was (41 ± 16) years, heart function grade IV, intravenous urapidil 4 ~ 10μg / (kg · min) 4h to maintain 3 ~ 5d. Results Urapidil can reduce total peripheral resistance, pulmonary vascular resistance, pulmonary capillary pressure and pulmonary arterial pressure, increase cardiac output and cardiac index. Heart function improved significantly in 13 cases, improvement in 2 cases, the total efficiency of 10%. Conclusion intravenous urapidil on left heart valve regurgitation caused by congestive heart failure has a good hemodynamic effect and clinical efficacy.