原发性骨髓增生异常综合征(MDS)病人的死亡,不仅可由于转变为急性粒细胞白血病,还可由于外周血细胞减少所引起的感染与出血所致。据认为 MDS是造血干细胞肿瘤性疾患,由于几乎没有正常的骨髓造血细胞存在,用强烈的细胞毒药物几乎达不到治疗目的。作者用13-顺维甲酸治疗8例 MDS。病人年龄36～84岁,男2、女6例,从未经治疗过。其中难治 The death of patients with primary myelodysplastic syndrome (MDS) not only due to the conversion to acute myeloid leukemia, but also due to peripheral blood cells caused by infection and bleeding. It is thought that MDS is a hematopoietic stem cell neoplastic disorder and almost no treatment with strong cytotoxic drugs exists due to the almost absence of normal myeloid hematopoietic cells. The authors treated 8 cases of MDS with 13-cis-retinoic acid. Patients aged 36 to 84 years old, male 2, female 6 cases, never treated. Which refractory