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目的观察丙泊酚联合咪唑安定用于无痛胃镜检查的临床效果。方法120例胃镜检查患者随机分成两组各60例,丙泊酚(A组)和丙泊酚复合咪唑安定(B组)。A组静注丙泊酚3mg/kg诱导,B组静注丙泊酚2mg/kg。检查前缓慢静注咪唑安定20μg/kg。待睫毛反射消失后开始操作,必要时每次追加丙泊酚30~50mg,记录两组诱导时间、苏醒时间、用药总量,呼吸循环参数改变和不良反应。结果术中丙泊酚总用量A组明显高于B组,苏醒时间A组长于B组。两组呼吸循环抑制发生率差异无显著性。结论丙泊酚联合小剂量咪唑安定用于无痛胃镜的检查,可减少丙泊酚用量,降低费用,苏醒时间短,镇痛满意,值得临床进一步推广应用。
Objective To observe the clinical effect of propofol combined with midazolam for painless gastroscopy. Methods 120 cases of gastroscopy were randomly divided into two groups of 60 cases, propofol (group A) and propofol combined with midazolam (group B). A group of intravenous propofol 3mg / kg induction, B group intravenous propofol 2mg / kg. Midazolam 20μg / kg intravenously before the test. After eyelash reflex disappeared, the operation was started. If necessary, propofol was added in an amount of 30-50 mg each time. Induction time, recovery time, total amount of medication, changes in breathing cycle parameters, and adverse reactions were recorded. Results The total amount of propofol in group A was significantly higher than that in group B, and the recovery time was longer in group A than in group B. There was no significant difference in the incidence of respiratory depression between the two groups. Conclusion Propofol combined with small dose of midazolam for painless gastroscopy can reduce the dosage of propofol, reduce costs, short recovery time, satisfactory analgesia, it is worth further clinical application.