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最近研究明确了阿耳茨海默病患者脑组织中脯氨酰内肽酶(PEP)活性增加,表明该酶参与阿耳茨海默病特有的淀粉样蛋白生成。因此期待PEP抑制剂能够成为该病的治疗药。在对和汉药中46种具有安神作用,对健忘有效的生药之PEP抑制剂进行筛选时,发现红景天(Rhodiola sacra的地下部分)的甲醇提取物显示强的抑制作用,故对其活性成分进行了探讨。
Recent studies have demonstrated increased activity of prolyl-endopeptidase (PEP) in the brain of patients with Alzheimer’s disease, suggesting that this enzyme is involved in the production of amyloid that is unique to Alzheimer’s disease. Therefore, it is expected that the PEP inhibitor can become a therapeutic drug for the disease. When screening for PEP inhibitors of 46 kinds of Chinese medicines and Han medicine, and screening of the biopharmaceutical PEP inhibitors effective for forgetfulness, it was found that the methanol extract of Rhodiola (the underground part of Rhodiola sacra) showed strong inhibitory action, so its activity The ingredients were explored.