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[Objective] To study the effects of ethanol extract of POLLEN TYPHAE(EEPT)on immune function in C57BL/6 tumor bearing mice.[Method] Taking tumor inhibition rate as index,antitumor activity of EEPT in vivo was investigated by establishing transplanted Lewis tumor mice.The tumor inhibition rate,spleen index and thymus index were respectively determined.The proliferation of spleen lymphocyte and contents of IL-2 and TNF-α in tumor bearing mice were respectively determined by MTT assay and ELISA method.[Result] 100 mg/kg·d EEPT had a significant inhibitory action on the growth of tumor,whose tumor inhibition rate was 48.3%.The three dose groups of EEPT could raise spleen index and thymus index.Meanwhile,100 and 200 mg/kg·d EEPT could significantly increase not only proliferation of spleen lymphocyte,but also the content of IL-2 and TNF-α.[Conclusion] EEPT could promote the function of humoral immunity and cellular immunity in C57BL/6 tumor bearing mice.
[Objective] To study the effects of ethanol extract of POLLEN TYPHAE (EEPT) on immune function in C57BL / 6 tumor bearing mice. [Method] Taking tumor inhibition rate as index, antitumor activity of EEPT in vivo was investigated by establishing transplanted Lewis tumor mice. The tumor inhibition rate, spleen index and thymus index were determined by the assay. The proliferation of spleen lymphocyte and contents of IL-2 and TNF-α in tumor bearing mice were detected by MTT assay and ELISA method. / kg · d EEPT had a significant inhibitory action on the growth of tumor, whose tumor inhibition rate was 48.3%. The three dose groups of EEPT could raise spleen index and thymus index. Meanwhile while 100 and 200 mg / kg · d EEPT could significantly increase not only proliferation of spleen lymphocytes, but also the content of IL-2 and TNF-a. [Conclusion] EEPT could promote the function of humoral immunity and cellular immunity in C57BL / 6 tumor bearing mice.