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目的:探讨Lennox-Gastaut综合征(LGS)的脑电图特点及痴灶定位。方法:回顾性总结、分析15例LGS患者的多道多形式脑电图特点,结合影像学资料并用辅助癫癎偶极子定位系统分析。结果:15例中,13例患者可见到癎样放电优势侧,其中9例已行手术治疗,术中7例行皮质及深部脑电图探测,证实了术前定位。随访6个月至2年,9例中发作停止6例,发作频率减少75％、50％- 75％和无效各1例,总有效率为89％,显效率为78％。结论:LGS表现复杂,特点鲜明,其脑电图异常程度高,虽然癎样放电广泛,但大部分可通过多形式多道脑电图找到其癎波发放优势侧,并结合病因、临床表现、影像学改变及偶极子拟合等,找出原发癎灶并予以手术切除,并同时联合胼胝体切开术,可获得良好的治疗效果。
Objective: To investigate the characteristics of EEG and the localization of Lenzox-Gastaut syndrome (LGS). Methods: A retrospective analysis of 15 cases of LGS patients with multi-channel EEG features, combined with imaging data and assisted epileptic dipole positioning system analysis. Results: Thirteen of 15 cases showed the superior discharge side, of which 9 cases had undergone surgical treatment. Seven cases underwent cortical and deep electroencephalography (PAG) detection during operation, confirming the preoperative localization. After 6 months to 2 years of follow-up, 6 patients stopped seizure in 9 patients. The frequency of seizures decreased by 75%, 50% -75%, and 1 invalid. The total effective rate was 89% and the effective rate was 78%. Conclusion: The performance of LGS is complex and distinctive. The abnormality of EEG is high. Although the discharge of LGS is extensive, most of them can be found by multimodal multi-channel electroencephalography (DEM) Imaging changes and dipole fitting, find the primary foci and surgical resection, combined with corpus callosum incision, can obtain a good therapeutic effect.