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对正常人及良、恶性胃疾病患者进行了微核测定。淋巴细胞微核出现率((?)±SE‰,下同)是:正常人3.40±0.26,胃癌为9.85±0.75,萎缩性胃炎为5.62±0.33,浅表性胃炎为4.86±0.23。胃癌与正常人、胃癌与两种胃炎之间均有非常显著的差异(P<0.001),两种胃炎与正常人之间均有显著差异(P<0.01),但两种胃炎之间无显著差异(P>0.05)。结果表明,胃癌患者外周血淋巴细胞微核出现率明显高于正常人和非癌胃病患者,说明该出现率反映了染色体畸变和损伤的程度。微核数随癌的恶性程度增加而增加,提示微核测定对癌的预后及复发的预测有一定意义。该方法可作为临床筛选胃癌的检测手段之一。
Micronucleus assays were performed on normal people and patients with benign and malignant gastric diseases. The frequency of lymphocyte micronucleus ((?)±SE‰, the same below) was 3.40±0.26 for normal persons, 9.85±0.75 for gastric cancer, 5.62±0.33 for atrophic gastritis, and 4.86±0.23 for superficial gastritis. There was a significant difference between gastric cancer and normal people, gastric cancer and both gastritis (P<0.001). There was a significant difference between the two gastritis and normal people (P<0.01), but there was no significant difference between the two gastritis. Difference (P>0.05). The results showed that the frequency of peripheral blood lymphocytes micronucleus in patients with gastric cancer was significantly higher than those in normal and non-cancerous gastric patients, indicating that the incidence reflects the degree of chromosome aberrations and injuries. The number of micronuclei increases with the degree of malignancy of the cancer, suggesting that micronucleus assay has certain significance for the prognosis of cancer and prediction of recurrence. This method can be used as one of the detection methods for clinical screening of gastric cancer.