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目的:观察肾综二甲汤配合西药治疗难治性肾病综合征的临床疗效。方法:将78例难治性肾病综合征患者随机分为两组,治疗组40例,对照组38例。对照组予激素加环磷酰胺及抗凝等对症治疗,治疗组在对照组治疗的基础上加服肾综二甲汤,疗程为1年,比较两组疗效。结果:治疗组完全缓解率40.0%,总有效率82.5%;对照组分别为26.3%及60.6%,治疗组疗效显著高于对照组(P<0.01)。治疗组治疗后24h尿蛋白定量、血浆白蛋白、血肌酐及尿素氮均较治疗前有明显改善(P<0.05~0.01)。结论:肾综二甲汤配合西药治疗难治性肾病综合征有较好疗效,显著优于单纯西药组。
Objective: To observe the clinical efficacy of Shen-Shen-A-Chuan Decoction combined with western medicine in the treatment of refractory nephrotic syndrome. Methods: 78 patients with refractory nephrotic syndrome were randomly divided into two groups, 40 cases in the treatment group and 38 cases in the control group. The control group was treated with cyclophosphamide and anticoagulant therapy. The treatment group was given Shenfu Erjia Tang on the basis of the control group, and the course of treatment was 1 year. The curative effect was compared between the two groups. Results: The complete remission rate was 40.0% and the total effective rate was 82.5% in the treatment group and 26.3% and 60.6% in the control group respectively. The therapeutic effect in the treatment group was significantly higher than that in the control group (P <0.01). After treatment, urinary protein, serum albumin, serum creatinine and urea nitrogen in treatment group were significantly improved 24 h after treatment (P <0.05-0.01). Conclusion: The therapeutic effect of Shen-Shen-Di-Tang Decoction combined with western medicine on refractory nephrotic syndrome is better than western medicine group.