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常染色体显性遗传性多囊肾病是常见遗传性肾脏疾病。虽然疾病早、中期,肾脏囊肿呈持续增大,但多数患者肾功能仍处于正常水平。因此,临床需能预测疾病发生、发展的敏感生物学标志物。总肾体积、肾血流量是已知预测常染色体显性遗传性多囊肾病进展的指标。肽素、中性粒细胞明胶酶蛋白、微小核糖核酸等也可能是早期预测常染色体显性遗传性多囊肾病的敏感指标。本文就常染色体显性遗传性多囊肾病早期诊断标志物的研究进展作一综述。
Autosomal dominant polycystic kidney disease is a common hereditary kidney disease. Although the disease early, mid, renal cysts showed a continuous increase, but most patients with renal function is still at normal levels. Therefore, the clinical need to predict the occurrence and development of sensitive biological markers. The total renal volume, renal blood flow, is an index that is known to predict the progress of autosomal dominant polycystic kidney disease. Peptin, neutrophil gelatinase protein, miRNA, etc. may also be sensitive indicators of early prediction of autosomal dominant polycystic kidney disease. This article reviews the progress of early diagnosis markers of autosomal dominant polycystic kidney disease.