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替硝唑(Tinidazole,TNZ)是继甲硝唑之后的新一代硝基咪唑类抗厌氧菌及抗原虫药,较甲硝唑疗效更高,耐受性更好,体内分布更广,我国1983年研制成功,目前已批量生产,投入临床使用。 1.药理作用 TNZ对脆弱类杆菌、拟杆菌、消化链球菌、棱形杆菌等所有厌氧以及滴虫、阿米巴原虫、兰伯氏贾弟虫等原微生物均有较强的抑制杀灭作用。其机理是TNZ进入易感的微生物细胞后,抑制细胞DNA的合成,并使已合成的DNA降解,破坏DNA的双螺旋结构或阻断其转录复制,从而使细胞死亡。
Tinidazole (TNZ) is a new generation of nitroimidazole anti-anaerobic bacteria and anti-protozoal after metronidazole, more effective than metronidazole, better tolerated, the body is more widely distributed in China in 1983 developed Success, has been mass-produced, put into clinical use. 1. Pharmacological effects TNZ Bacteroides fragilis, Bacteroides, Peptostreptococcus, Prus, and all other anaerobic and Trichomonas, amoeba, Lambertia and other microbes have a strong inhibitory and killing effect. The mechanism is that after TNZ enters susceptible microbial cells, it inhibits the synthesis of cellular DNA, degrades the synthesized DNA, destroys the double helix structure of DNA, or blocks its transcriptional replication, thereby causing cell death.