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染色体畸变的细胞是一种研究基因表达的对象。在这些细胞中许多酶的活性、代谢产物成分有很大的变化,细胞本身以至整个机体的生命力也可能降低。根据现代资料可以推测,在染色体畸变的细胞里,从遗传学水平,代谢和酶不平衡的形成取决于三个主要因素:(1)结构基因数量变化在表型表达水平的“剂量效应”;(2)调节基因数量变化引起它所控制的结构基因功能失调,不包括染色体畸变,这是调节基因的剂量效应;(3)在代谢产物不平衡的影响下诱导
Chromosome-distorting cells are an object of studying gene expression. In these cells, many enzymes have a great change in activity and metabolite components, and the vitality of the cells themselves and the entire body may also decrease. According to modern data, it can be inferred that in chromosomal aberration cells, the formation of metabolic and enzyme imbalances depends on three major factors from the genetic level: (1) “dose effect” of changes in the number of structural genes in phenotypic expression; (2) Regulatory changes in the number of genes that cause structural gene dysfunction controlled by it do not include chromosomal aberrations, which is the dose effect of regulatory genes; (3) induced under the influence of metabolite imbalance