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根据慢性乙型肝炎病毒(HBV)持续感染与宿主免疫功能低下有关的理论,我们自1982年起与有关单位合作对免疫增强剂猪苓多糖治疗慢性乙型肝炎进行了前瞻性研究。到1985年7月止共治疗319例,取得了一定的效果。在此基础上,从1086年10月起,我们试用猪苓多糖联合小剂量(2μg)乙肝疫苗反复注射治疗慢性乙型病毒性肝炎患者,试图打破机体对HBV感染的免疫耐受,促使乙型肝炎表面抗体(HBsAb)阳转,增强免疫调节剂的作用,探索彻底清除HBV感染的方法和途径。到1989年7月共治疗乙型肝炎e抗原(HBeAg)阳性的慢性乙型病毒性肝炎126例。现将结果报告如下。
According to the theory of chronic hepatitis B virus (HBV) persistent infection and host immune dysfunction, we conducted a prospective study of the immunopotentiator Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B since 1982 in cooperation with relevant agencies. By July 1985 a total of 319 cases were treated, and achieved some results. On this basis, starting from October 1086, we tried to use repeated doses of Polyporus umbellatus polysaccharide combined with low dose (2μg) hepatitis B vaccine in patients with chronic hepatitis B to try to break the body’s immune tolerance to HBV infection, Hepatitis B surface antigen (HBsAb) positive rotation, enhance the role of immunomodulatory agents to explore ways and means to completely eliminate HBV infection. To July 1989 were treated with hepatitis B e antigen (HBeAg) -positive chronic hepatitis B 126 cases. The results reported below.