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目的 :观察在心脏骤停期间应用大剂量肾上腺素的同时给以血管升压素及苯福林治疗后的效果 ;方法 :首先应用肾上腺素 1 .0mg和 5.0mg ,若无效时可重复用药的同时加用血管升压素 0 .5u/kg和 1 0u/kg,每隔 1 0分钟重复首剂量 ,同时在肾上腺素用 2次～ 7次后加用苯福林 5mg～ 1 0mg ,每隔 1 0分钟用药一次 ;结果 :心肺复苏中应用上述 3种药物后其自主循环恢复率为 6 6 .7% ,明显高于单小剂量肾上腺素的自主循环恢复率 ;结论 :苯福林可增强心脏起搏 ,减少心肌耗氧量 ,大剂量血管升压素可增加心脏排出量 ,改善组织代谢 ,比单用肾上腺素能明显地提高自主循环恢复率 ,改善患者生存机会。
OBJECTIVE: To observe the effects of vasopressin and phenylephrine treatment during cardiac arrest using high-dose epinephrine. Methods: First, epinephrine 1.0 mg and 5.0 mg were given, and if not effective, At the same time plus vasopressin 0.5u / kg and 10u / kg, every 10 minutes repeat the first dose, while in 2 to 7 times the epinephrine plus phenylephrine 5mg ~ 10mg, every 1 0 minutes medication once; Results: Cardiopulmonary resuscitation in the application of the above three drugs its spontaneous circulation recovery was 66.7%, significantly higher than single-dose epinephrine autonomic recovery rate; Conclusion: phenylephrine can be enhanced Cardiac pacing, reduce myocardial oxygen consumption, high-dose vasopressin can increase cardiac output, improve tissue metabolism than single adrenergic can significantly improve the recovery rate of spontaneous circulation, improve patient survival opportunities.