The Yellow River Basin(YRB)is characterized by active geological and tectonic processes,rapid geomorphological evolution,and distinct climatic diversity.Correspondingly,major disasters in the YRB are characterized by varied types,extensive distributions,and sudden occurrences.In addition,major disasters in the YRB usually evolve into disaster chains that cause severe consequences.Therefore,major disasters in the YRB destroy ecologies and environments and influence geological and ecological safety in the basin.This paper systematically reviews research on geological and surface processes,major disaster effects,and risk mitigation in the YRB,discusses the trends and challenges of relevant research,analyzes the key scientific problems that need to be solved,and suggests prospects for future research based on the earth system science concept.Themes of research that should be focused on include geological,surface and climatic processes in the YRB and their interlinking disaster gestation mechanisms;formation mechanisms and disaster chain evolutions of giant landslides in the upper reach of the YRB;mechanisms and disaster chain effects of loess water-soil disasters in the middle reach of the YRB;occurrence patterns and amplifying effects of giant flood chains in the lower reach of the YRB;and risk mitigations of major disasters in the YRB.Key scientific problems that need to be solved are as follows:how to reveal the geological,surface and climatic processes that are coupled and interlinked with gestation mechanisms of major disasters;how to clarify the mutual feedback effects between major disasters and ecology;and how to develop a human-environmental harmony-based integrated risk mitigation system for major disasters.Prospects for future studies that follow the earth system science concept include the following:highlighting inter-disciplinary research to reveal the interlinked disaster gestation mechanisms of the geology,surface and climate in the YRB in the past,present,and future;forming theories to clarify the regional patterns,dynamic mechanisms,and mutual-feedback effects between disaster chains and ecology in the YRB on land and in rivers in the region;solving technological bottlenecks to develop assessment models and mitigation theories for integrated risks in the YRB by following the human-environment harmony concept;and finally,establishing a demonstratable application pattern characterized by“whole-basin coverage”and“zonal controls”,thereby guaranteeing ecological and geological safety in the basin and providing scientific support for ecological conservation and high-quality development of the YRB.