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离子敏感型原位凝胶为高分子溶液剂,其形成机制是利用高分子辅料对外界刺激(体内外不同的生理环境—离子强度)的响应,使高分子辅料在生理条件下发生分散状态或构象的可逆变化,完成由溶液向凝胶的转化过程[1]。离子敏感型鼻用原位凝胶作为一种极具开发潜力的药物传递系统,兼备制备简单、使用方便、组织相容性和生物黏附性以及控制释药性能良好的优势。目前国内尚未制订离子敏感型原位凝胶的质量控制标准,本文针对国内外离子敏感型原位凝胶的制剂质量研究的报道进行综述,旨在为离子敏感型鼻用原位凝胶给药系统的
Ion-sensitive in situ gel polymer solution, the formation of the mechanism is the use of polymer excipients on the external stimuli (in vivo and in different physiological environment - ionic strength) response, the polymer excipients dispersed under physiological conditions or state Conformation reversible change, complete the conversion from solution to gel [1]. Ion-sensitive nasal in situ gel is a promising drug delivery system with advantages of simple preparation, easy to use, histocompatibility and bioadhesion and controlled drug delivery. At present, the quality control standards for ion-sensitive in-situ gels have not been established in our country. In this paper, the reports of preparation quality studies of ion-sensitive in situ gels at home and abroad are reviewed in this paper. systematic