A 400-mm-long stalagmite from Tangshan Cave, Nanjing has beenanalyzed by a high-precision TIMS-U series dating method and also determined for oxygen and carbon stable isotopic compositions. The results provided a high-resolution paleoclimate record for eastern China during a time interval (from 54 000 to 19 000 aBP) of the last glaciation. The continuous record of oxygen-18 variations in the stalagmite, indicating a precipitation history of the East Asian monsoon, shows not only signals of the Heinrich events, but also the Dansgaard-Oeschger cycles which are first found in the last glacial climate record of the East Asian monsoon area. Although the stalagmite-based climatic signals match well with the GRIP ice core record, some differences between the two re-cords can be recognized: (1) The last glacial climate changes in eastern China exhibited a long-term remarkably cooling trend, superimposed on which were four successive Bond’s cycles illus-trated by the δ18O curve. This strong cooling tendency may be an effect of the strong summer mon-soon event during the MIS 3 over the Tibetan Plateau. (2) There exist some phase differences of 1000—2000 years between the cooling events in the stalagmite-based climate signal and the GRIP ice core record. Such differences should be further verified by calibrations of multiple dating meth-ods.