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给麻醉大鼠静脉注射 ZnSO_4、CuSO_4及 MgSO_4,观察心率、收缩压、舒张压、平均动脉压、左室收缩压、左室压变化速率最大值、左室收缩成分缩短最大速度、等容舒张期心室内压下降时间常数 T 值等指标。结果表明,ZnSO_4具有抑制心肌舒缩功能、减慢心率和增加外周阻力的作用;大剂量 CuSO_4可抑制心功能,增加外周阻力;MgSO_4具有抑制心肌收缩功能、降低血压、减慢心率的作用。
Intravenous injection of ZnSO 4, CuSO 4 and MgSO 4 into anesthetized rats, heart rate, systolic pressure, diastolic pressure, mean arterial pressure, left ventricular systolic pressure, maximal rate of change of left ventricular pressure, maximal velocity of systolic left ventricular systolic velocity, Ventricular pressure drop time constant T value and other indicators. The results showed that ZnSO_4 could inhibit heart function and reduce heart rate and increase peripheral resistance. High dose of CuSO_4 could inhibit cardiac function and increase peripheral resistance. MgSO_4 could inhibit myocardial contractile function, lower blood pressure and lower heart rate.