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目的探讨尿激酶静脉溶栓治疗急性脑梗死的有效治疗时间窗。方法 40例发病在6 h内的急性脑梗死患者,随机分为观察组和对照组,各20例。两组患者入院后均给予溶栓治疗,观察组在发病3 h内进行治疗,对照组在发病3~6 h内进行治疗,比较两组患者的临床效果。结果观察组患者神经功能缺损评分明显低于对照组(P<0.05);观察组脑出血并发症明显低于对照组(P<0.05);观察组进行溶栓治疗1周后的疗效明显优于对照组(P<0.05)。结论运用尿激酶静脉溶栓治疗急性脑梗死时,要在3 h时间窗内进行治疗,且越早治疗效果越好,能够有效改善患者治疗效果,降低患者的脑出血并发症和神经功能缺损。
Objective To investigate the effective treatment time window of intravenous thrombolytic therapy of urokinase for acute cerebral infarction. Methods Forty patients with acute cerebral infarction within 6 hours were randomly divided into observation group and control group with 20 cases in each. Both groups were given thrombolytic therapy after admission. The observation group was treated within 3 hours of onset, while the control group was treated within 3 to 6 hours of onset. The clinical effects of the two groups were compared. Results The score of neurological deficit in the observation group was significantly lower than that of the control group (P <0.05). The complication of cerebral hemorrhage in the observation group was significantly lower than that of the control group (P <0.05). One week after the thrombolytic therapy in the observation group, Control group (P <0.05). Conclusions The treatment of acute cerebral infarction with urokinase intravenous thrombolysis should be treated within the time window of 3 h, and the sooner the treatment effect is better, the treatment effect of the patients can be effectively improved and the complications of cerebral hemorrhage and neurological deficits are reduced.