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黄曲霉毒素B_1(AFB_1)是某些黄曲霉菌菌株的代谢产物。不少实验证明它具有强烈的致肝癌作用。某些地区,尤其热带地区的流行病学研究也表明它与肝癌的发病有关。另一方面,近年来另一强致癌物,二甲基亚硝胺(DMN)也受到人们的密切关注。本文旨在研究DMN与AFB_1的协同致肝癌作用。实验用布法罗大鼠。分别喂以含1 ppmAFB_1,25 ppm DMN,以及1ppm AFB_1加25ppm DMN的饲料共6个月,然后换以普通饲料。于实验开始后3、6、9及12个月把动物处死检查。结果表明,对照组动物无一例
Aflatoxin B_1 (AFB_1) is a metabolite of certain Aspergillus flavus strains. Many experiments show that it has a strong role in causing liver cancer. Epidemiological studies in some areas, especially in the tropics, also indicate that it is associated with the development of liver cancer. On the other hand, in recent years another strong carcinogen, dimethylnitrosamine (DMN) has also been closely watched. This article aims to study the synergistic effect of DMN and AFB_1 on liver cancer. Experimental Buffalo rats. The animals were fed a feed containing 1 ppm AFB_1, 25 ppm DMN, and 1 ppm AFB_1 plus 25 ppm DMN for 6 months, respectively, and then fed a regular feed. The animals were sacrificed 3, 6, 9 and 12 months after the start of the experiment. The results show that the control group of animals without a case