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AIM:To study the expression of myeloid-related proteins(MRP)8 and myeloid-related proteins(MRP)14 in humanesophageal squamous cell carcinoma and to investigate ifthere was any correlation between MRP8 and MRP14expression level and histopathological grade in thesetumors.METHODS:In this study,65 cases of advanced esophagealsquamous cell carcinoma were assessed for MRP8 andMRP14 expression using immunohistochemistry.Statisticalanalysis was performed for the comparison of MRP8 andMRP14 expression in normal and tumor tissues,and theirrelationship with clinicopathological features.RESULTS:Reduced or absent expression of MRP8 and MRP14was observed in esophageal squamous cell carcinoma,witha significant difference between tumor tissues and normaltissues (P<0.01 and P<0.01 for MRP8 and MRP14,respectively).Poorly differentiated tumors presented a greater decreasethan well and moderately differentiated tumors,with acorrelation between their protein level and histopathologicalgrading (P<0.001 and P<0.001,respectively).However,nosignificant association was found between MRP8 and MRP14expression and age or gender (P>0.05).CONCLUSION:These findings suggest that the decreasedexpression of MRP8 and MRP14 might play an importantrole in the pathogenesis of human esophageal squamouscell carcinoma,being particularly associated with poordifferentiation of tumor cells.
AIM: To study the expression of myeloid-related proteins (MRP) 8 and myeloid-related proteins (MRP) 14 in humanesophageal squamous cell carcinoma and to investigate if there was any correlation between MRP8 and MRP14 expression level and histopathological grade in these tumors. METHODS: In this study, 65 cases of advanced esophageal squamous cell carcinoma were assessed for MRP8 and MRP14 expression using immunohistochemistry. Statistical analysis was performed for the comparison of MRP8 and MRP14 expression in normal and tumor tissues, and their relationship with clinicopathological features .RESULTS: Reduced or absent expression of MRP8 and MRP 14 was observed in esophageal squamous cell carcinoma, witha significant difference between tumor tissues and normal tissues (P <0.01 and P <0.01 for MRP 8 and MRP 14, respectively) .Poorly differentiated tumors presented a greater decreased well and moderately differentiated tumors, with acorrelation between their protein level and histopathologicalgrading (P <0.001 and P <0.001, respectively). However, nosignificant association was found between MRP8 and MRP14 expression and age or gender (P> 0.05). CONCLUSION: These findings suggest that the decrease in expression of MRP8 and MRP14 might play an importantrole in the pathogenesis of human esophageal squamous cell carcinoma, is particularly associated with poordifferentiation of tumor cells.