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目的探讨胱蛋白酶抑制剂C(Cys C)在恶性高血压急性肾损伤早期诊断中的意义。方法对我院2007-2008年恶性高血压的32例患者进行血清肌肝(Scr)、光蛋白酶抑制剂(Cys C)、24 h尿肌肝检测,观察CysC在急性肾损伤早期时的变化特点。结果 Cys C在恶性高血压患者急性肾损伤时增高有统计学差异(P<0.01),GFR下降亦有统计学差异(P<0.05),两者之间差异无统计学意义。结论 Cys C在恶性高血压急性肾损伤能较好或更早地反应肾小球滤过率(GFR)的变化,可作为早期诊断指标之一。
Objective To investigate the significance of cystatin C (Cys C) in the early diagnosis of acute renal injury induced by hypertension. Methods Thirty-two patients with malignant hypertension in our hospital from 2007 to 2008 were examined for serum Cys C, Cys C and 24 h urinary liver. The changes of CysC in the early stage of acute renal injury were observed . Results Cys C was significantly increased in acute renal injury patients with malignant hypertension (P <0.01), while GFR decreased significantly (P <0.05). There was no significant difference between the two groups. Conclusion Cys C can respond to glomerular filtration rate (GFR) better or earlier in patients with acute renal injury of hypertension, which may be used as one of the early diagnostic indicators.