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目的分析急性心肌梗死患者应用不同类型他汀类药物匹伐他汀和普伐他汀的疗效。方法将120例首次发生心肌梗死患者随机分为匹伐他汀2mg组(n=61)和普伐他汀10mg组(n=59),进行12个月的随访观察,检测LDL胆固醇等血脂指标,并观察治疗后冠心病、脑卒中、非致死性心肌梗塞等心血管事件。结果匹伐他汀组比普伐他汀组降低LDL胆固醇水平更加明显,但普伐他汀组比匹伐他汀组显著降低急性冠脉综合征发生率。结论匹伐他汀可明显降低急性心肌梗塞发病后患者LDL胆固醇和总胆固醇,而普伐他汀则在降低心肌梗塞、心肌缺血和非致死性中风等心血管事件发生风险更为明显。
Objective To analyze the efficacy of different types of statins pitavastatin and pravastatin in patients with acute myocardial infarction. Methods 120 patients with first myocardial infarction were randomly divided into two groups: pitavastatin 2mg group (n = 61) and pravastatin 10mg group (n = 59), followed up for 12 months. LDL cholesterol and other lipid indicators Observed after treatment of coronary heart disease, stroke, non-fatal myocardial infarction and other cardiovascular events. Results The level of LDL cholesterol in pravastatin group was more obvious than that in pravastatin group, but the incidence of acute coronary syndrome was significantly decreased in pravastatin group and pitavastatin group. Conclusion Pitavastatin can significantly reduce the LDL cholesterol and total cholesterol in patients with acute myocardial infarction, while pravastatin is more effective in reducing the incidence of cardiovascular events such as myocardial infarction, myocardial ischemia and non-fatal stroke.