引起旅游者腹泻的产毒性大肠杆菌(ETEC)分泌与霍乱毒素抗原性相关的不耐热肠毒素(LT),在孟加拉国妇女和儿童的大范围试验中发现服用B亚单位/全细胞霍乱菌苗(BS-WC)可对ETEC引起的腹泻有3个月的预防作用,保护率为86%。本文预期的双盲法研究证明了BS-WC对芬兰集体去摩洛哥的成年旅游者腹泻有部分的保护作用。参加试验的有615名旅游者,307名和308名分别随机空腹服用BS-WC或安慰剂(EcoliK-12)。BS-WC每剂中含有1×10~(11)热灭活的霍乱全细胞和1mg霍乱毒素的B亚单位。每 Toxin-producing Escherichia coli (ETEC) causing diarrhea in tourists secretes heat-labile enterotoxin (LT) associated with cholera toxin antigenicity and is found in large-scale trials in Bangladeshi women and children taking B subunit / whole cell cholera BS-WC can prevent ETEC-induced diarrhea by 3 months, with a protection rate of 86%. The prospective double-blind study in this article demonstrates that BS-WC has a partial protective effect on diarrhea among adult tourists going to Morocco collectively. A total of 615 tourists, 307 and 308 were randomized to receive either fasting BS-WC or placebo (Ecoli K-12). BS-WC contains 1 x 10-11 heat-inactivated cholera whole cells and 1 mg cholera toxin B subunit per dose. each