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【目的】探讨机器人房间隔缺损修补术治疗成人继发性房间隔缺损患者的临床疗效。【方法】回顾性分析本院收治的110例继发性房间隔缺损患者的临床资料，根据治疗方法的不同将其分为观察组（行机器人房间隔缺损修补术，n=57）和对照组（行经导管介入封堵术，n=53）。比较两组患者手术时间、住院时间、术后输血率，比较两组患者术后并发症发生情况。比较两组患者术前及术后6个月右心房直径（RA）、右心室直径（RV）、左心房直径（LA）、左心室直径（LV）。【结果】观察组与对照组手术均成功，观察组手术时间、住院时间和术后输血均明显高于对照组，差异有统计学意义（P<0.05）。术后6个月，观察组和对照组患者RA、RV均低于术前，差异有统计学意义（P0.05）；观察组术后6个月RA、RV明显低于对照组，差异有统计学意义（P<0.05）。观察组术后并发症发生率为5.26%（3/57），低于对照组的24.53%（13/53），差异有统计学意义（χ2=8.200，P=0.004＜0.05）。【结论】机器人房间隔缺损修补术在治疗成人继发性房间隔缺损的过程中发挥着重要的作用，能够显著降低术后RA、RV，同时具有较高的临床安全性。nn|%【Objective】To investigate the clinical effect of robot repair of atrial septal defect in adult patients. 【Methods】The clinical data of 110 patients with secondary atrial septal defect admitted to our hospital were retrospectively analyzed. According to the different treatment methods, they were divided into observation group (robot atrial septal defect repair, n=57) and control group (transcatheter closure, n=53). The operation time, hospital stay, postoperative blood transfusion rate and postoperative complications were compared between the two groups. The right atrial diameter (RA), right ventricular diameter (RV), left atrial diameter (LA) and left ventricular diameter (LV) were compared between the two groups before and 6 months after operation.【Results】The operation time, hospital stay and postoperative blood transfusion in the observation group were significantly higher than those in the control group (P<0.05). 6 months after operation, RA and RV in observation group and control group were lower than those before operation, the difference was statistically significant (P0.05); RA and RV of observation group were significantly lower than those of control group at 6 months after operation, the difference was statistically significant (P<0.05). The incidence of postoperative complications in the observation group was 5.26% (3/57), which was lower than 24.53% (13/53) of the control group, and the difference was statistically significant (χ2=8.200, P=0.004<0.05).【Conclusion】Robot atrial septal defect repair plays an important role in the treatment of adult secondary atrial septal defect. It can significantly reduce postoperative RA and RV, and has high clinical safety.nn