Rodents are the main host animals that spread plague, and Spermophilus dauricus(S. dauricus) is the most common rodent in North China. In this study, a rodent density survey was carried out in China’s Jilin Province from April to August 2005. Moran’s I and semivariogram curves were used to investigate the spatial distribution characteristics of the sampling data. We found that the spatial auto-correlation index was low and failed to generate a meaningful semivariogram curve. In this case, commonly used interpolators, such as kriging, were not suitable for mapping density over the study area. However, the Sandwich model, which is based on spatial stratified heterogeneity, could be applied to our data. Our results showed that the type of soil and land use significantly influenced the distribution of rodent density, and the interactive effect of these variables was much stronger than that of each variable alone. The Sandwich-estimated rodent density map showed that rodent density increased from the southeast to the northwest in Jilin Province. Finally, a framework of a rodent density survey using the Sandwich model was introduced.