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目的 :研究二甲基亚砜及尼莫地平对大鼠血液中梭曼消除的影响 ,并就其作用机制做进一步探索。方法 :测定大鼠血液中梭曼残留浓度及组织中羧酸酯酶 (CaE)活性。结果 :4 15μg/kg梭曼( 5LD50 )iv后 ,二甲基亚砜及尼莫地平均能降低大鼠血中的梭曼残留浓度 ;二甲基亚砜预处理还能明显加深梭曼对大鼠肠道及血浆中CaE的抑制程度。结论 :二甲基亚砜通过提高机体解毒酶的利用度 ,能加速梭曼在大鼠血液中的消除。
Objective: To study the effect of dimethylsulfoxide (DMSO) and nimodipine on the elimination of soman in the blood of rats and to explore its mechanism of action. Methods: To determine the residual Soman concentration and carboxylesterase (CaE) activity in the blood of rats. Results: DMSO and nimodipine all decreased the soman’s residual concentration in the blood of the rats after 4 15μg / kg sohumal (5LD50) iv, DMSO pretreatment could significantly enhance the soman’s Inhibition of CaE in intestinal and plasma of rats. Conclusion: DMSO can accelerate the elimination of soman in rat blood by increasing the availability of detoxification enzymes in the body.