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二甲双胍是一安全有效的抗糖尿病药物,已被广泛推荐为治疗2型糖尿病的一线用药。随着对二甲双胍研究的深入,发现其作用不仅局限于降低糖尿病患者血糖,且对多囊卵巢综合征和非酒精性脂肪肝病等也有一定益处。此外,二甲双胍可通过激活腺苷酸活化蛋白激酶,抑制哺乳动物雷帕霉素靶蛋白通路等阻滞癌症细胞生长。近年来,其抗动脉粥样硬化、改善血管内皮功能等对心血管的保护作用也成为研究的热点。
Metformin is a safe and effective antidiabetic drug and has been widely recommended as first-line therapy for type 2 diabetes. With the further study of metformin, we found that its role is not limited to reducing blood glucose in diabetic patients, and polycystic ovary syndrome and non-alcoholic fatty liver disease also have some benefits. In addition, metformin can activate the activation of adenylate protein kinase, inhibition of mammalian target of rapamycin pathway and other cancer cell growth. In recent years, its anti-atherosclerosis and improve vascular endothelial function on the cardiovascular protective effect has also become a research hot spot.