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近来研究越来越多地发现凝血功能紊乱通常是恶性肿瘤的首发迹象。现在已经证实,肿瘤导致血栓形成的风险增加,而凝血功能的过度激活也极大地影响肿瘤的进展。在肺癌患者中,存在着持续的凝血刺激。癌细胞通过组织因子(tissuefactor,TF)的表达激活凝血功能;通过凝血酶的表达和促凝血微粒的释放等影响凝血功能。凝血功能也通过介导血小板释放其颗粒内容物、抑制自然杀伤细胞和募集巨噬细胞而促进肿瘤的进展。非小细胞肺癌(non-small cell lung cancer,NSCLC)占肺癌的80%-85%,本文就凝血系统各个组分在NSCLC发生发展中的病理生理学机制的最新研究进展进行综述。
Recently, more and more studies have found that coagulation disorders are usually the first signs of malignancy. It has now been demonstrated that tumors increase the risk of thrombosis, whereas over-activation of coagulation also greatly affects tumor progression. In lung cancer patients, there is a constant clotting stimulus. Cancer cells activate the coagulation function through the expression of tissue factor (TF), and influence the coagulation function through the expression of thrombin and the release of procoagulant particles. Coagulation also promotes tumor progression by mediating the release of its particulate contents by platelets, inhibiting natural killer cells and recruiting macrophages. Non-small cell lung cancer (NSCLC) accounts for 80% -85% of lung cancer. This review summarizes the recent progress in the pathophysiology of the development of various components of the coagulation system in NSCLC.