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原发性温抗体型自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)是由于不明病因导致B淋巴细胞功能紊乱产生红细胞自身抗体,进而导致红细胞过多过早破坏而发生溶血性贫血。最新报告显示AIHA的年发病率为0.8~3.0/10万,死亡率达到11%~([1])。根据致病抗体作用于红细胞最佳活性温度可将AIHA分为3类:①温抗体型(w AIHA):自身抗体与红细胞反应最佳温度为37℃,抗体主要为IgG型;②冷抗体型:包括冷凝集
Primary autoimmune hemolytic anemia (autoimmune hemolytic anemia, AIHA) is due to unknown causes of B lymphocyte dysfunction produce red blood cell autoantibodies, leading to premature erythrocyte destruction and the occurrence of hemolytic anemia. The latest report shows the annual incidence of AIHA 0.8 ~ 3.0 / 100 000, the mortality rate reached 11% ~ ([1]). AIHA can be divided into three groups according to the optimal activity temperature of erythrocytes: w AIHA: the optimal temperature for the autoantibodies to react with erythrocytes is 37 ℃, the main antibody is IgG type; ② cold antibody type : Including condensation set