论文部分内容阅读
为探讨血清泌乳素（ＰＲＬ）与乳腺癌发生、发展的关系。对１１７例乳腺增生病、３６例乳腺纤维腺瘤及５１例乳腺癌患者进行了血清ＰＲＬ含量的测定，对１７例乳腺癌及２１例纤维腺瘤患者进行了雌激素受体的测定。结果显示：轻度乳腺增生、早期乳腺癌患者血清ＰＲＬ含量与正常对照组比较无显著性差异（Ｐ＞０．０５），重度乳腺增生、瘤样增生及纤维腺瘤患者均较轻度增生者的血清ＰＲＬ含量增高（Ｐ＜０．０１）；不同期别的乳腺癌患者，其血清ＰＲＬ含量随期别的增加而显著增高（Ｐ＜０．０１）。提示血清ＰＲＬ含量增高是促进乳腺癌发展的重要因素。
To explore the relationship between serum prolactin (PRL) and the occurrence and development of breast cancer. Serum PRL levels were measured in 117 cases of breast hyperplasia, 36 cases of breast fibroadenoma, and 51 cases of breast cancer. Estrogen receptors were measured in 17 cases of breast cancer and 21 cases of fibroadenoma. The results showed that serum PRL levels in patients with mild breast hyperplasia and early breast cancer were not significantly different from those in normal controls (P>0.05). Patients with severe breast hyperplasia, neoplastic hyperplasia, and fibroadenoma were mild hyperplasias. Serum PRL levels increased (P<0.01); in different stages of breast cancer, serum PRL levels increased significantly (P<0.01). It suggests that the increase of serum PRL is an important factor in promoting the development of breast cancer.