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家兔静注肾上腺素(10～500μg/kg)和去甲肾上腺素(1～500μg/kg)后,光镜下显示心肌细胞呈灶性浊肿,胞浆嗜伊红染色增强,有的心肌细胞发生空泡变性和收缩带形成。电镜观察显示肾上腺素和去甲肾上腺素所引起的心肌细胞的超微结构改变相仿,表现为心肌内线粒体明显肿胀,嵴断裂、崩解、消失,严重时可呈空泡状,部分线粒体膜碎裂。心肌细胞内糖原颗粒减少,部分肌原纤维呈收缩状态或断裂成碎片状,胞核内染色质减少。心肌内毛细血管内皮细胞水肿伴大量空泡形成,引起管腔狭窄或堵塞。肾
Rabbits intravenous injection of epinephrine (10 ~ 500μg / kg) and norepinephrine (1 ~ 500μg / kg), the light microscope showed focal necrosis of myocardial cells, cytoplasmic eosin staining increased, and some myocardial Cells undergo vacuolar degeneration and contraction band formation. Electron microscopy showed that epinephrine and norepinephrine induced myocardial cell ultrastructure changes similar to the performance of myocardial mitochondria was significantly swelling, crista fracture, disintegration, disappearance of severe vacuolar, some mitochondrial membrane fragmentation crack. Myocardial glycogen granules reduced, some myofibril contraction or broken into fragments, reduced chromatin in the nucleus. Myocardial capillary endothelial cell edema with a large number of vacuoles, causing lumen stenosis or blockage. kidney