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目的 :研究抑癌基因 Rb、MTS1 的表达与膀胱癌的预后。方法 :用 S- P免疫组化法同步检测 6 0例膀胱移行细胞癌抑癌基因 Rb、MTS1的表达 ,观察其与预后的关系。结果 :PRb、p16表达阳性组生存率明显优于阴性组。结论 :PRb与 p16均具有膀胱癌的预后价值 ,而同步检测两者的预后价值优于单一检测。
Objective: To study the expression of tumor suppressor gene Rb, MTS1 and the prognosis of bladder cancer. Methods: The expression of tumor suppressor gene Rb and MTS1 in 60 cases of bladder transitional cell carcinoma was detected synchronously by S-P immunohistochemistry. The relationship between the expression of Rb and MTS1 was observed. Results: The survival rates of PRb and p16 positive group were significantly better than those of negative group. Conclusion: Both PRb and p16 have the prognostic value of bladder cancer, while the synchronous detection of both prognostic value is better than a single test.