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肿瘤是由肿瘤细胞和周围间质构成,间质成分包括各种各样的间叶细胞、大量的成纤维细胞、肌成纤维细胞、内皮细胞、外膜细胞以及与免疫系统有关的炎症细胞。肿瘤的发生发展并非由上皮或间质单方面决定,而是由两者相互作用所构成的肿瘤—宿主界面微环境的平衡状态所决定。肿瘤相关成纤维细胞与肿瘤进展的各个阶段都有关,能产生生长因子、趋化因子和促进内皮细胞和外膜细胞的募集的细胞外基质。因此,肿瘤相关成纤维细胞是恶性肿瘤进展过程中一个重要的决定因素并且可能成为抗肿瘤治疗的重要靶点。
Tumor is composed of tumor cells and surrounding stroma, interstitial components including a variety of mesenchymal cells, a large number of fibroblasts, myofibroblasts, endothelial cells, adventitial cells and immune system-related inflammatory cells. The development of tumors is not determined unilaterally by the epithelium or stroma, but rather by the equilibrium state of the tumor-host interface microenvironment formed by the interaction of the two. Tumor-associated fibroblasts are involved in all stages of tumor progression and can produce growth factors, chemokines and extracellular matrices that promote the recruitment of endothelial cells and adventitial cells. Therefore, tumor-associated fibroblasts are an important determinant of malignant tumor progression and may be important targets for anti-tumor therapy.