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目的观察口服美沙拉嗪(5-ASA)联合糖皮质激素灌肠治疗轻、中度远端活动性溃疡性结肠炎(UC)的临床疗效。方法采用随机对照法选取94例轻、中度远端活动性UC患者,随机分为病例组48例及对照组46例,病例组给予口服5-ASA,每次1.0g,每日三次,同时给予地赛米松5mg加入0.2%黄莲素溶液100ml每晚保留灌肠;对照组给予口服5-ASA,每次1.0g,每日三次,疗程均为8周,同时复查结肠镜,观察组织学的变化。结果口服5-ASA联合糖皮质激素灌肠组与口服5-ASA组治疗UC总有效率分别为91.67%和76.09%,显效率分别为66.67%和36.96%,两组间比较有显著性差异(P<0.05)。两组的不良反应比较无显著差异(P>0.05)。结论口服5-ASA联合糖皮质激素灌肠治疗轻、中度远端活动性UC疗效优于口服5-ASA,不良反应发生率无明显差异。
Objective To observe the clinical efficacy of oral mesalazine (5-ASA) combined with glucocorticoid enema in the treatment of mild to moderate distal ulcerative colitis (UC). Methods Ninety-four patients with mild to moderate distal active UC were enrolled in the randomized controlled trial. They were randomly divided into 48 cases in the case group and 46 cases in the control group. The cases were given oral 5-ASA orally at 1.0g three times a day, Administration of 5 mg of dexamethasone followed by 100 ml of 0.2% pristinil solution retained enema each night. The control group received orally administered 5-ASA 1.0 g twice daily for 8 weeks. Colonoscopy was followed to review the histological changes. Results The total effective rates of oral administration of 5-ASA combined with glucocorticoid enema and oral administration of 5-ASA were 91.67% and 76.09%, respectively. The effective rates were 66.67% and 36.96%, respectively. There was significant difference between the two groups (P <0.05). Adverse reactions between the two groups showed no significant difference (P> 0.05). Conclusion Oral 5-ASA combined with glucocorticoid enema treatment of mild to moderate distal end-UC better than oral 5-ASA, the incidence of adverse reactions no significant difference.