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目的：评价１０３７４例细菌性感染病人不做皮试口服青霉素Ｖ的安全性及有效性。方法：青霉素Ｖ２５０～５００ｍｇ，ｐｏ，ｔｉｄ，疗程５ｄ。结果：参加疗效评定９０６３例，显效率４２．１８％（３８２３／９０６３例），总有效率８１．１８％（７３５７／９０６３例）。１９３０例病人用药前后做细菌培养，１１６３例阳性，共培养出致病菌１１６３株，治疗后细菌清除９６０株（８２．５５％）。不良反应发生率０．７４％（７６／１０３１１例），４４例因不良反应在治疗中被迫停药，主要为胃肠道反应。过敏反应发生率低，仅为０．１８％。但没有一例病人出现过敏性休克。１５３８例病人用药前后做了肝、肾功能检查：２例ＡＬＴ升高，发生率为０．１３％（２／１５３８）。结论：不做皮试口服青霉素Ｖ治疗细菌感染是安全有效的。
Objective: To evaluate the safety and efficacy of oral administration of penicillin V in 10374 patients with bacterial infection without skin test. Methods: penicillin V250 ~ 500mg, po, tid, treatment 5d. Results: 9063 cases participated in curative effect evaluation, the effective rate was 42.18% (3823/9063 cases), the total effective rate was 81.18% (7357/9063 cases). 1930 patients before and after treatment of bacterial culture, 1163 cases were positive, a total of 1163 strains of pathogens were cultured after treatment, bacteria cleared 960 (82.55%). The incidence of adverse reactions was 0.74% (76/10311 cases), 44 cases were discontinued due to adverse reactions during treatment, mainly gastrointestinal reactions. The incidence of allergic reaction is low, only 0.18%. But none of the patients had anaphylactic shock. Before and after treatment of 1538 patients with liver and kidney function tests: 2 patients with elevated ALT, the incidence was 0.13% (2/1538). CONCLUSION: It is safe and effective to treat penicillin V without bacterial test.